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Active CI Questions
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As part of our initiative to help approved CI authors submit question proposals, we will be sharing all current and active questions that various authors are working on at the different CI sites across the country.

Click HERE to access an archive our past CI questions. 

Here is the list of active CI questions: 


  1. In adults aged 50-69 with no prior history of coronary artery or cerebrovascular disease, does low dose (81mg) aspirin daily reduce risk of cardiovascular disease/events (MI and stroke)? 
  2. In patients with osteoarthritis, which oral non-opioid agents are most effective at reducing pain? 
  3. How commonly does long-term PPI therapy cause clinically significant hypomagnesium (hypomagnesia)?



  1.  What is the role of aspirin in colon cancer risk prevention?



  1. Is bridging coumadin before screening colonoscopy in patients with atrial fibrillation beneficial for reducing the risk of stroke?
  2. Is bridging coumadin in patients with sub-theraputic INRs who have chronic atrial fibrillation and an elevated CHADS score beneficial for reducing the risk of stroke?
  3. How much is the risk of stroke increased in chronic atrial fibrillation and a abnormal CHADs score on coumadin with subtherapeutic INRs?
  4. What are the risks of harm associated with long term use of proton pump inhibitors (PPIs) to control symptoms of gastrointestinal esophageal reflux disease (GERD) in patients over the age of 65 years?
  5. Are oral NSAIDs equivalent to other oral analgesics for relieving pain in the first several days following an acute musculoskeletal injury?
  6. Does diabetic education by a diabetic educator improve diabetes control in patients with type 2 diabetes?
  7. Is rivaroxaban as effective as vitamin K antagonists in the treatment of DVT and PE?
  8. Is rivaroxaban as safe as vitamin K antagonists in the treatment of DVT and PE?



  1. Is intra-articular platelet-rich plasma (PRP) an effective treatment for osteoarthritis of the knee?
  2. Does statin therapy alter the risk or progression of dementia?
  3. What are effective medical therapies for gastroparesis? 
  4. How safe and effective is fecal transplant in preventing C. diff recurrence? 
  5. What is the best anticoagulant treatment for venous thromboembolic (VTE) disease in patients with cancer?
  6. How well do completed physician’s orders for life-sustaining treatment (POLST) result in the patient getting the type of end-of-life care that they wanted?
  7. Does amniotomy shorten spontaneous labor or improve birth outcomes?
  8. How effective are ACE inhibitors and ARBs for the prevention of migraines?



  1. Is Cognitive Behavioral Therapy effective in the treatment of adult insomnia disorder?



  1. What are the risks and benefits of steroids for women with later preterm labor (34weeks0days through 36 weeks6 days)?
  2. Is pericoital use of oral emergency contraceptives a safe and effective form of long-term birth control?




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